We’re thrilled to be joined by Alice, who has been working in Danny Huang’s lab at the CRUK Scotland Institute, first for her PhD then a short postdoc. Alice will be exploring the manipulation of novel E3 ligases for targeted protein degradation, a topic she is very familiar with!

We’re delighted for Emma who was awarded first prize in this year’s Microbiology Society award ceremony in London! Emma delivered her talk on the antiviral duality of OAS2.

We’re very lucky to welcome Harry who joins us from Sheila Graham’s lab. Harry will be using microscopy and mass spectrometry to monitor targets of RNF213 ubiquitin ligases activity.

This year we have the pleasure of hosting Allison Ward and Alegna Calderon Nunez for summer research projects. Allison is studying Molecular and Cellular Biology at the University of Glasgow and secured an Wellcome Trust Vacation Scholarship award to fund this project, while Alegna is on the University of Glasgow’s Infection Biology MSc programme. We…

Our paper describing the metabolic regulation of giant E3 ubiquitin ligase RNF213 by the well-known energy currency ATP, is out now in Nature Communications. Here we used an activity-based probe of cysteine E3 activity, with Cryo-EM and protein biochemistry, to dissect the basic requirements of RNF213 E3 activation by the small molecule ATP. By developing a…

5 members of the Fletcher Lab flew or trained their way to Heidelberg last week for the Innate Immune meeting at the EMBL. Eilidh, Emma, Hollie and Arda presented posters, and Arda was awarded an EMBO poster prize for his poster, entitled ‘ATP is a correlate of infection sensed by broad antimicrobial RNF213’ – well…

Eilidh presented a poster on her work on antiviral enzyme ZNFX1, at the School of Infection and Immunity’s annual postgraduate poster competition. The event includes students from across the School, comprising virologists, parasitologists and bacteriologists. A judging panel awarded Eilidh’s poster 3rd place – well done Eilidh!

We’re delighted to welcome Aidan Tollervey to the lab for the practical element of his MSc in Infection Biology. Aidan will undertake a 3 month research project, supervised by Eilidh and Emma, exploring how coronaviruses intersect with RNA binding E3 ligases.

Eilidh, Arda and Adam attended the famous Ub&Friends meeting last week, organised by the Austrian SFB Targeted Protein Degradation consortium. We spent a few days with our friends in the Clausen lab (see Collaborators) and discussing exciting science with the ubiquitin community. Adam gave a short talk describing our new method for identifying E3 activity…